Apolipoprotein A1-derived amyloid in human aortic atherosclerotic plaques
1995 (English)In: American Journal of Pathology, ISSN 0002-9440, E-ISSN 1525-2191, Vol. 147, no 5, 1186-1192 p.Article in journal (Refereed) Published
Amyloid deposits in the aortic intima are very common in association with atherosclerosis and aging. In the present study, a major fibril protein purified from amyloid present in human atherosclerotic plaques was shown to be a 69-amino acid N-terminal fragment of apolipoprotein AI. Although senile form of localized apolipoprotein AI-derived amyloidosis has recently been documented in pulmonary vessels of dogs, this is the first example of a localized human amyloid derived from this apolipoprotein.
Place, publisher, year, edition, pages
1995. Vol. 147, no 5, 1186-1192 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-79733PubMedID: 7485381OAI: oai:DiVA.org:liu-79733DiVA: diva2:544069