Celecoxib does not appear to affect prosthesis fixation in total knee replacement
2009 (English)In: Acta Orthopaedica, ISSN 1745-3674, Vol. 80, no 1, 46-50 p.Article in journal (Refereed) Published
Background and purpose: After joint replacement, a repair process starts at the interface between bone and cement. If this process is disturbed, the prosthesis may never become rigidly fixed to the bone, leading to migration and with time loosening. Cox-2 inhibitors are widely used as postoperative analgesics, and have adverse effects on bone healing. This could tamper prosthesis fixation. We investigated if celecoxib, a selective Cox-2 inhibitor, increases prosthesis migration in total knee replacement (TKR).
Methods: 50 patients were randomized to either placebo or celecoxib 200mg twice daily during 3 weeks after TKR (NexGen®, Zimmer). Maximum total point motion (MTPM) of the tibial component was measured after 2 years using radiostereometric analysis (RSA). In addition, range of motion, pain, and, subjective outcome were evaluated.
Results: No differences in prosthesis migration, pain scores, range of motion or subjective outcome were found after 2 years. Confidence intervals were narrow.
Interpretation: Celecoxib is not likely to increase the risk of loosening and may be used safely in conjunction with TKR.
Place, publisher, year, edition, pages
2009. Vol. 80, no 1, 46-50 p.
IdentifiersURN: urn:nbn:se:liu:diva-15110DOI: 10.1080/17453670902804976OAI: oai:DiVA.org:liu-15110DiVA: diva2:54409