liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
Mem Sloan Kettering Cancer Centre, USA.
Mem Sloan Kettering Cancer Centre, USA.
University of Cambridge, England.
University of Cambridge, England.
Show others and affiliations
2012 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 6Article in journal (Refereed) Published
Abstract [en]

Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I-2 = 49.3%; p = less than0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95% CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.

Place, publisher, year, edition, pages
Public Library of Science , 2012. Vol. 7, no 6
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-79692DOI: 10.1371/journal.pone.0035706ISI: 000305892100001OAI: oai:DiVA.org:liu-79692DiVA: diva2:544120
Available from: 2012-08-13 Created: 2012-08-13 Last updated: 2017-12-07

Open Access in DiVA

fulltext(387 kB)1829 downloads
File information
File name FULLTEXT01.pdfFile size 387 kBChecksum SHA-512
00e9c93b58df54127b388099e1eb0f75f44c3c50849647a7145dc840252c70991addce0bec2abf24ba62267a7cc04c9e8f8e35ef6633949cc0c187047e926371
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Stenmark Askmalm, Marie

Search in DiVA

By author/editor
Stenmark Askmalm, Marie
By organisation
OncologyFaculty of Health SciencesDepartment of Clinical Pathology and Clinical Genetics
In the same journal
PLoS ONE
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 1829 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 109 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf