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Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Dermatology and Venerology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Dermatology and Venerology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Dermatology and Venerology in Östergötland.
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2012 (English)In: Pigment Cell & Melanoma Research, ISSN 1755-1471, E-ISSN 1755-148X, Vol. 25, no 4, 506-513 p.Article in journal (Refereed) Published
Abstract [en]

Genetic variants of NLRP3 and NLRP1 are known to modulate levels of pro-inflammatory cytokine interleukin (IL)-1 beta. The purpose of this study was to investigate the association of NLRP3/NLRP1 polymorphisms with susceptibility and clinical features of malignant melanoma in a Swedish casecontrol study. Common variants in NLRP3/NLRP1 were investigated in sporadic malignant melanoma patients and healthy controls followed by analysis using logistic regression. NLRP3 variant (rs35829419) was significantly more common in male patients than in controls (OR, 2.22; CI, 1.273.86). Upon stratification, significant association with nodular melanoma was observed (OR, 2.89; CI, 1.336.30), which intensified in male patients (OR 4.03, CI 1.4011.59). The NLRP1 variant (rs12150220) was significantly more common in fair-skinned female patients (OR, 1.85; CI, 1.043.33) and showed strong associations with nodular melanoma (OR, 6.03; CI, 1.3325). Our data suggest that NLRP3/NLRP1 polymorphisms are associated with melanoma susceptibility; these findings warrant validation in other independent populations.

Place, publisher, year, edition, pages
Blackwell Publishing , 2012. Vol. 25, no 4, 506-513 p.
Keyword [en]
inflammasome; NLRP1; NLRP3; CIAS1; SNP; melanoma; IL-1 ss
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-79688DOI: 10.1111/j.1755-148X.2012.01008.xISI: 000305511200015OAI: oai:DiVA.org:liu-79688DiVA: diva2:544136
Available from: 2012-08-13 Created: 2012-08-13 Last updated: 2017-12-07

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Verma, DeeptiBivik, CeciliaSynnerstad, IngridFredrikson, MatsEnerbäck, CharlottaRosdahl, IngerSöderkvist, Peter

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Verma, DeeptiBivik, CeciliaSynnerstad, IngridFredrikson, MatsEnerbäck, CharlottaRosdahl, IngerSöderkvist, Peter
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Cell BiologyFaculty of Health SciencesDermatology and VenerologyDepartment of Dermatology and Venerology in ÖstergötlandOccupational and Environmental Medicine
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Pigment Cell & Melanoma Research
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