Autoantibodies to leucocyte antigens in hydralazine-associated nephritis
1992 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 231, no 1, 37-42 p.Article in journal (Refereed) Published
Clinical and laboratory findings and drug history were studied in 17 patients with suspected hydralazine-associated nephritis, five of whom only had renal disease, while twelve also had extrarenal manifestations. Renal biopsies revealed extracapillary proliferative or focal segmental proliferative glomerulonephritis in 10 patients, and tubulo-interstitial nephritis in five patients. Antinuclear antibody (ANA) was found in 16 patients, but none of the 14 patients tested had antibodies to DNA. Tests for antibodies to myeloperoxidase (anti-MPO) and antibodies to neutrophil cytoplasm antigen (ANCA) were performed by ELISA. Twelve of the 14 patients tested had anti-MPO; five of these 14 patients had ANCA, while one had borderline levels. These findings suggest that hydralazine facilitates the induction of a systemic disease with multiple autoantibody production.
Place, publisher, year, edition, pages
1992. Vol. 231, no 1, 37-42 p.
ANA, ANCA, anti-MPO, hydralazine, systemic lupus erythematosus, vasculitis
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-79903DOI: 10.1111/j.1365-2796.1992.tb00496.xOAI: oai:DiVA.org:liu-79903DiVA: diva2:544544