Long term changes in abdominal symptoms in irritable bowel syndrome (IBS): A 7-year follow-up study in 37 outpatients
(English)Manuscript (preprint) (Other academic)
Background The natural course of abdominal symptoms in IBS is sparsely known. Our aim was to study the long-term change in daily symptoms in a sample of outpatients.
Methods Sixty-three outpatients kept a record of daily symptoms over a 6-week period. Several years later they were asked to repeat the recordings during one fortnight and to answer questions regarding their health between the studies. The dairy cards were analysed by cluster analysis to identify symptom subgroups. Changes in symptoms were assessed by analysis of variance.
Results The median follow-up time was 7 years. Thirty-seven patients participated. One patient claimed to be symptom-free between studies while the others were symptomatic. At the present study 31 patients claimed to suffer abdominal symptoms consistent with IBS while 6 patients were asymptomatic. According to the daily records pain and straining decreased while normal stools increased. Gender and illness duration, use of medication and subgroup placement did not affect these changes and the subgroups were similarly distinguished from each other in both study periods. During baseline the six symptom-free patients all belonged to the pain subgroup characterised by little pain and bloating and four of them to the bowel habit subgroup characterised by normal stools and the least disturbed stool passage.
Conclusions The abdominal symptoms remained fairly unchanged. The clinical course and prognosis is possibly predicted according to subgroup.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-79968OAI: oai:DiVA.org:liu-79968DiVA: diva2:544899