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Swedish Lung Cancer Radiation Study Group: Predictive value of age at diagnosis for radiotherapy response in patients with non-small cell lung cancer
Uppsala University Hospital, Sweden .
Gävle Hospital, Sweden .
Uppsala University Hospital, Sweden .
Uppsala University Hospital, Sweden .
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2012 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 51, no 6, 759-767 p.Article in journal (Refereed) Published
Abstract [en]

Introduction. The aim of the present study was to investigate the impact of age at diagnosis on prognosis in patients treated with curatively intended radiotherapy for NSCLC. Material and methods. This is a joint effort among all the Swedish Oncology Departments that includes all identified patients with a diagnosed non-small cell lung cancer that have been subjected to curatively intended irradiation (andgt;= 50 Gy) treated during 1990 to 2000. Included patients had a histopathological/cytological diagnosis date as well as a death date or a last follow-up date. The following variables were studied in relation to overall and disease-specific survival: age, gender, histopathology, time period, smoking status, stage and treatment. Results. The median overall survival of all 1146 included patients was 14.7 months, while the five-year overall survival rate was 9.5%. Younger patients (andlt;55 years), presented with a more advanced clinical stage but had yet a significantly better overall survival compared with patients in the age groups 55-64 years (p = 0.035) and 65-74 years (p = 0.0097) in a multivariate Cox regression analysis. The overall survival of patients aged andgt;= 75 years was comparable to those aged andlt;55 years. Conclusion. In this large retrospective study we describe that patients younger than 55 years treated with curatively intended radiotherapy for NSCLC have a better overall survival than patients aged 55-64 and 65-74 years and that younger patients seem to benefit more from the addition of surgery and/or chemotherapy to radiotherapy. Due to the exploratory nature of the study, these results should be confirmed in future prospective trials.

Place, publisher, year, edition, pages
Informa Healthcare , 2012. Vol. 51, no 6, 759-767 p.
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-79986DOI: 10.3109/0284186X.2012.681064ISI: 000306480600010OAI: diva2:544947

Funding Agencies|Stiftelsen Gavle Cancerfond||

Available from: 2012-08-17 Created: 2012-08-17 Last updated: 2012-08-23

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Department of Respiratory Medicine UHL
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