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Role of Tobacco Use in the Etiology of Acoustic Neuroma
Ohio State University, USA .
Ohio State University, USA .
Karolinska Institute, Sweden .
Karolinska Institute, Sweden .
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2012 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 175, no 12, 1243-1251 p.Article in journal (Refereed) Published
Abstract [en]

Two previous studies suggest that cigarette smoking reduces acoustic neuroma risk; however, an association between use of snuff tobacco and acoustic neuroma has not been investigated previously. The authors conducted a case-control study in Sweden from 2002 to 2007, in which 451 cases and 710 population-based controls completed questionnaires. Cases and controls were matched on gender, region, and age within 5 years. The authors estimated odds ratios using conditional logistic regression analyses, adjusted for education and tobacco use (snuff use in the smoking analysis and smoking in the snuff analysis). The risk of acoustic neuroma was greatly reduced in male current smokers (odds ratio (OR) = 0.41, 95% confidence interval (CI): 0.23, 0.74) and moderately reduced in female current smokers (OR = 0.70, 95% CI: 0.40, 1.23). In contrast, current snuff use among males was not associated with risk of acoustic neuroma (OR = 0.94, 95% CI: 0.57, 1.55). The authors findings are consistent with previous reports of lower acoustic neuroma risk among current cigarette smokers than among never smokers. The absence of an association between snuff use and acoustic neuroma suggests that some constituent of tobacco smoke other than nicotine may confer protection against acoustic neuroma.

Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy B , 2012. Vol. 175, no 12, 1243-1251 p.
Keyword [en]
acoustic neuroma; cigarette smoking; smoking; snuff; snus; Swedish snuff; tobacco; vestibular schwannoma
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-79796DOI: 10.1093/aje/kwr465ISI: 000305419400005OAI: diva2:544987
Available from: 2012-08-17 Created: 2012-08-14 Last updated: 2014-09-10

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Harder, Henrik
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Oto-Rhiono-Laryngology and Head & Neck SurgeryFaculty of Health SciencesDepartment of Otorhinolaryngology in Linköping
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