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Clinical characteristics and mortality risk in relation to obstructive and central sleep apnoea in community-dwelling elderly individuals: a 7-year follow-up
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL.ORCID iD: 0000-0001-7431-2873
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Neurophysiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Neurophysiology UHL.
Linköping University, Department of Medical and Health Sciences, Cardiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Cardiology UHL.ORCID iD: 0000-0001-6353-8041
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2012 (English)In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 41, no 4, 468-474 p.Article in journal (Refereed) Published
Abstract [en]

Methods: a total of 331 community-dwelling elderly aged 71-87 years underwent a clinical examination and one-night polygraphic recordings in their homes. Mortality data were collected after seven years. Results: a total of 55% had SDB, 38% had OSA and 17% had CSA. Compared with those with no SDB and OSA, more participants with CSA had a left ventricular ejection fraction less than 50% (LVEF less than 50%) ischaemic heart disease (IHD) and transient ischaemic attack (TIA)/stroke. There was no difference in the rate of IHD and TIA/stroke between OSA and no SDB, but more LVEF less than 50% was found in those with OSA. CSA significantly increased the risk for all-cause (P = 0.002) and CV mortality (P = 0.018) by more than two times. After adjustments for CV disease, diabetes and the biomarker NT-pro-brain natriuretic peptide CSA associations to all-cause mortality and CV mortality lost significance. Conclusion: OSA, in persons greater than 75 years does not appear to be associated with cardiovascular disease (CVD) disease or mortality, whereas CSA might be a pathological marker of CVD and impaired systolic function associated with higher mortality.

Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy A , 2012. Vol. 41, no 4, 468-474 p.
Keyword [en]
elderly; obstructive sleep apnoea; central sleep apnoea; mortality
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-79785DOI: 10.1093/ageing/afs019ISI: 000305628500009OAI: oai:DiVA.org:liu-79785DiVA: diva2:545003
Available from: 2012-08-17 Created: 2012-08-14 Last updated: 2017-12-07

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Johansson, PeterAlehagen, UrbanSvanborg, EvaDahlström, UlfBroström, Anders

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