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Proteome of Coxiella burnetii
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Dep. Microbiology and Molecular Genetics, Oklahoma State University, USA.
Institute of Virology, Slovak Academy of Science, Bratislava, Slovakia.
2012 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 984, 105-130 p.Article in journal (Refereed) Published
Abstract [en]

Recent proteomic studies of C. burnetii, the etiological agent of Q fever, have brought a deeper insight into the pathogens physiology and offered new possibilities in investigations of inter- or intra-species relatedness. The data generated from these studies in conjunction with the current genomic sequence databases may reveal additional identities for conserved and unique C. burnetii biomarkers and aid in creating algorithms and/or databases that could develop into diagnostic and detection tools for the pathogen. Moreover, wide scale screening and further characterization of potential C. burnetii protein antigens along with a comprehensive evaluation of the humoral immune response will be of fundamental importance towards research and development of a safe and efficacious vaccine as well as improved serodiagnostic tests for rapid and sensitive detection of the Q fever pathogen. Given these advances, proteomics may make marked contributions to the improvement of human health protection against C. burnetii in the coming years.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2012. Vol. 984, 105-130 p.
National Category
Microbiology in the medical area
URN: urn:nbn:se:liu:diva-80251DOI: 10.1007/978-94-007-4315-1_6ISI: 000333215000007PubMedID: 22711629OAI: diva2:546322
Available from: 2012-08-23 Created: 2012-08-23 Last updated: 2015-10-12Bibliographically approved

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