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Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohns disease
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery UHL.
2012 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1258, no 1, 125-134 p.Article in journal (Refereed) Published
Abstract [en]

The ability to control uptake across the mucosa and protect from harmful substances in the gut lumen is defined as intestinal barrier function. The etiology of Crohns disease is unknown, but genetic, environmental, and immunological factors all contribute. The frontline between these factors lies in the intestinal barrier. The most important inflammation-driving environmental factor in Crohns disease is the microbiota, where Esherichia coli strains have been assigned a key role. The first observable signs of Crohns disease are small aphtoid ulcers over Peyers patches and lymphoid follicles. The overlaying follicle-associated epithelium (FAE) is specialized for luminal sampling and is an entry site for antigens and bacteria. We have demonstrated increased E. coli uptake across the FAE in Crohns disease, which may initiate inflammation. This short review will discuss barrier dysfunction and bacteria in the context of ileal Crohns disease, and how the FAE might be the site of initial inflammation.

Place, publisher, year, edition, pages
2012. Vol. 1258, no 1, 125-134 p.
Keyword [en]
adherent invasive E. coli; etiology; inflammatory bowel disease; pathogens; Peyer's patches
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-80250DOI: 10.1111/j.1749-6632.2012.06502.xOAI: oai:DiVA.org:liu-80250DiVA: diva2:546327
Available from: 2012-08-23 Created: 2012-08-23 Last updated: 2017-12-07

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Keita, Åsa V.Söderholm, Johan D.

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CiteExportLink to record
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  • apa
  • harvard1
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  • Other style
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  • de-DE
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