Does healing of an osteochondral defect with or without a periosteal autograft involve a local sprouting of nerve fibres?: An experimental study on the rat patella
(English)Manuscript (preprint) (Other academic)
Repair of articular cartilage is an important clinical problem. Availability of chondrogenic stem cells has been pointed out as one key factor in cartilage repair and application of periosteal autografts has been used clinically to improve healing. In addition, neuropeptide containing nerve fibres may contribute to healing by stimulating cell proliferation and/or differentiation. In the rat, peptidergic nerve fibres invade the callus formation during fracture healing and peptidergic nerve fibres are abundant in cartilage related connective tissue during skeletal development in young mammals. The purposes of the present study were to evaluate healing of an experimental full thickness osteochondral defect in the rat patella with and without application of a periosteal autograft, and to find out if a local nerve sprouting is part of the healing process. Osteochondral healing was evaluated with a histological score and the presence of nerve fiber profiles in relation to the defect was assessed by protein gene product 9.5 immunohistochemistry. The results showed (i) that osteochondral defects in the rat patella heal spontaneously but incompletely, (ii) that healing consistently is less satisfactory with application of a periosteal autograft than without and (iii) that healing is not accompanied by nerve fibre sprouting.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-80302OAI: oai:DiVA.org:liu-80302DiVA: diva2:546475