Fibrils from Synthetic Amyloid-Related Peptides Enhance Development of Experimental AA-Amyloidosis in Mice
1994 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 199, no 1, 306-312 p.Article in journal (Refereed) Published
Amyloid enhancing factor is an incompletely characterized activity of extracts from many amyloid-containing tissues and which greatly shortens the preamyloidotic phase during experimental induction of AA-amyloidosis. In this communication we show that amyloid-like fibrils made in vitro from synthetic peptides, corresponding to segments of amyloid fibril proteins, have amyloid enhancing factor-like activity. Thus, there is a possibility that amyloid enhancing factor activity depends on small fibrils serving as nucleation centers for fibril elongation.
Place, publisher, year, edition, pages
1994. Vol. 199, no 1, 306-312 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-80889DOI: 10.1006/bbrc.1994.1229OAI: oai:DiVA.org:liu-80889DiVA: diva2:548983