Long-term enhancement of the lgG2 antibody response to Haemophilus influenzae type b by breastfeeding
(English)Manuscript (preprint) (Other academic)
Subjects. Sets of sera were obtained from 30 children below 6 years of age with invasive Haemophilus influenzae type b (Hib) infection, and therr mothers. DuratiOn and mode of breastfeeding were registered. Levels of IgG1, IgG2, IgA and IgM antibodies agamst Hrb capsular polysaccharide (CP) were determined in sera taken during acute the illness as well as in the early and late convalescence.
Results. Children 18 months or older with longer duration of exclusive breastfeeding (13 weeks or more, mean 19.3 weeks) had higher anti-Rib antibody levels of the IgG1, IgG2, IgA and IgM isotypes than those with shorter duration of exclusive breastfeeding (less than 13 weeks, mean 5.4 weeks). The difference between the breastfeeding groups was greatest for the IgG2 isotype. In regression analyses the association between the duration of exclusive breastfeeding and the anti-Hib IgG2 level was significant when breastfeeding, type of Hib infection, maternal anti-Rib antibody level and age were used as explanatory factors. In the group of 14 children below 18 months of age no significant differences were noted.
Discussion. Human milk is rich in IFN-y as well as in IFN-y producing cells, which may result in a specific stimulatory effect of breastfeeding on the IgG2 anti-Rib antibody response. In conclusion, this study indicates the presence of a long lasting enhancing effect of breastfeeding on the antibody response to Hib in children, in particular on IgG2 anti-Hib antibody production.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-81108OAI: oai:DiVA.org:liu-81108DiVA: diva2:550502