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Intracerebral quantitative chromophore estimation from reflectance spectra captured during deep brain stimulation implantation
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0012-7867
2013 (English)In: Journal of Biophotonics, ISSN 1864-063X, E-ISSN 1864-0648, Vol. 6, no 5, 435-445 p.Article in journal (Refereed) Published
Abstract [en]

Quantification of blood fraction (fblood), blood oxygenation (S), melanin, lipofuscin and oxidised and reduced Cytochrome aa 3 and c was done from diffuse reflectance spectra captured in cortex, white matter, globus pallidus internus (GPi) and subthalamus during stereotactic implantations of 29 deep brain stimulation (DBS) electrodes with the aim of investigating whether the chromophores can give physiological information about the targets for DBS. Double-sided Mann-Whitney U -tests showed more lipofuscin in GPi compared to white matter and subthalamus (p < 0.05). Compared to the other structures, fbloodwas significantly higher in cortex (p < 0.05) and S lower in GPi (p < 0.05). Median values and range for fblood were 1.0 [0.2–6.0]% in the cortex, 0.3 [0.1–8.2]% in white matter, 0.2 [0.1–0.8]% in the GPi and 0.2 [0.1–11.7]% in the subthalamus. Corresponding values for S was 20 [0–81]% in the cortex, 29 [0–78]% in white matter, 0 [0–0]% in the GPi and 0 [0–92]% in the subthalamus. In conclusion, the measurements indicate very low oxygenation and blood volume for DBS patients, especially in the GPi. It would be of great interest to investigate whether this is due to the disease, the normal situation or an artefact of doing invasive measurements.

Place, publisher, year, edition, pages
Weinheim: Wiley-VCH Verlagsgesellschaft, 2013. Vol. 6, no 5, 435-445 p.
Keyword [en]
diffuse reflectance spectroscopy;deep brain stimulation;subthalamic nucleus (STN);globus pallidus internus (GPi);blood oxygen saturation;absorption coefficient
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-81381DOI: 10.1002/jbio.201200055ISI: 000318363000010OAI: oai:DiVA.org:liu-81381DiVA: diva2:552094
Available from: 2012-09-12 Created: 2012-09-12 Last updated: 2017-12-07Bibliographically approved

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Johansson, JohannesWårdell, Karin

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