External Ophthalmoplegia Associated With Hashimotos Thyroiditis and Recovered on Corticosteroid Treatment
2012 (English)In: The American journal of surgery, ISSN 0002-9629, E-ISSN 1538-2990, Vol. 344, no 2, 151-152 p.Article in journal (Refereed) Published
Five-year follow-up of a young male patient is presented. Total external ophthalmoplegia developed 1 week after an upper respiratory tract infection. After 3 years of the course, hyperthyreosis and clinical signs of thyroid-associated ophthalmopathy occurred. Hashimotos thyroiditis and ultrastructural signs of mitochondrial damage of striated muscle were found by histological investigations. The paresis of the external ocular muscles recovered after long-term corticosteroid treatment. On the basis of clinical symptoms and histological results, the authors supposed that an immunological reaction had caused mitochondrial damage in the striated muscles, which also resulted in thyroiditis. This case history points that autoimmune mechanism more frequently might participate in the pathogenesis of chronic external ophthalmoplegia, and the symptoms might precede organ-specific or perhaps systemic autoimmune disorders.
Place, publisher, year, edition, pages
Lippincott, Williams and Wilkins , 2012. Vol. 344, no 2, 151-152 p.
External ophthalmoplegia, Hashimotos thyroiditis, Corticosteroid treatment
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-81506DOI: 10.1097/MAJ.0b013e31824d4d93ISI: 000306966300015OAI: oai:DiVA.org:liu-81506DiVA: diva2:553097