liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Mobilized peripheral blood stem cells compared with bone marrow from HLA-identical siblings for reduced-intensity conditioning transplantation in acute myeloid leukemia in complete remission: a retrospective analysis from the Acute Leukemia Working Party of EBMT
Chaim Sheba Medical Centre, Israel .
UPMC University of Paris, France .
Chaim Sheba Medical Centre, Israel .
Kings Coll London, England .
Show others and affiliations
2012 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 89, no 3, 206-213 p.Article in journal (Refereed) Published
Abstract [en]

Reduced-intensity conditioning (RIC)-alloSCT is increasingly used for acute myelogenous leukemia. Limited data are available for the comparison of peripheral blood stem cells with bone marrow for RIC-alloSCT. We used the European Group for Blood and Marrow Transplantation (EBMT) ALWP data to compare the outcome of mobilized peripheral blood stem cells (PBSC) (n = 1430) vs. bone marrow (BM) (n = 107) for acute myelogenous leukemia (AML) patients with complete remission that underwent RIC-alloSCT from compatible sibling donors. The leukemia features, the disease status, and the time from diagnosis were similar between the two groups. Engraftment was achieved in 99% and 93% in the PBSC and BM groups, respectively (P andlt; 0.0001). The day of engraftment was significantly earlier for the PBSC vs. the BM group, 15 (159) and 19 (569), respectively (P andlt; 0.001). Acute GVHD, severe GVHD (grade IIIIV) and chronic GVHD did not differ between the groups. leukemia-free survival (LFS), relapse, and non-relapsed mortality (NRM) were 51 +/- 2%, 32 +/- 1%, and 17 +/- 1% vs. 50 +/- 6%, 38 +/- 6%, and 12 +/- 3% for the PBSC and BM groups, respectively. Our results indicate faster engraftment, but no difference in GVHD, LFS, relapse, and NRM when comparing PBSC to BM grafts from sibling donors following RIC conditioning. This is the first study comparing PBSC to BM grafts in the RIC setting, analyzing a homogeneous population of patients with AML in remission. Whether PBSC should be preferred for advanced phases of the disease, where the outcome is dominated by relapse incidences, needs further investigation.

Place, publisher, year, edition, pages
John Wiley and Sons , 2012. Vol. 89, no 3, 206-213 p.
Keyword [en]
acute myelogenous leukemia, allogeneic stem cell transplantation, reduced-intensity conditioning, mobilized peripheral blood stem cells, remission, HLA matched sibling
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-81498DOI: 10.1111/j.1600-0609.2012.01811.xISI: 000307476800003OAI: diva2:553115
Available from: 2012-09-18 Created: 2012-09-18 Last updated: 2012-09-18

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Malm, Claes
By organisation
OncologyFaculty of Health SciencesDepartment of Haematology UHL
In the same journal
European Journal of Haematology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link