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Proteomic research in bivalves Towards the identification of molecular markers of aquatic pollution
University of Porto, Portugal .
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
University of Porto, Portugal University of Porto, Portugal .
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-3894-2218
2012 (English)In: Journal of Proteomics, ISSN 1874-3919, Vol. 75, no 14, 4346-4359 p.Article, review/survey (Refereed) Published
Abstract [en]

Biomonitoring of aquatic environment and assessment of ecosystem health play essential roles in the development of effective strategies for the protection of the environment, human health and sustainable development. Biomarkers of pollution exposure have been extensively utilized in the last few decades to monitor the health of organisms and hence assess environmental status. However, the use of single biomarkers against biotic or abiotic stressors may be limited by the lack of sensitivity and specificity. Therefore, more recently, the search for novel biomarkers has been focused on the application of OMICS methodologies. Environmental proteomics focuses on the analysis of an organisms proteome and the detection of changes in the level of individual proteins/peptides in response to environmental stressors. Proteomics can provide a more robust approach for the assessment of environmental stress and therefore exposure to pollutants. This review aims to summarize the proteomic research in bivalves, a group of sessile and filter feeding organisms that play an important function as "sentinels" of the aquatic environment. A description of the main proteomic methodologies is provided. The current knowledge in bivalves toxicology, achieved with proteomics, is reported describing the main biochemical markers identified. A brief discussion regarding future challenges in this area of research emphasizing the development of more descriptive gene/protein databases that could support the OMICs approaches is presented. less thanbrgreater than less thanbrgreater thanThis article is part of a Special Issue entitled: Farm animal proteomics.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 75, no 14, 4346-4359 p.
Keyword [en]
Bivalves, Environmental toxicology, Proteomics, Biomarkers
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-81834DOI: 10.1016/j.jprot.2012.04.027ISI: 000307023900012OAI: diva2:556593

Funding Agencies|Swedish Research Council-Natural Science and Medicine (VR-M and VR-NT)||Carl Trygger Foundation||VINNOVA-Vinnmer program||Magnus Bergvalls Foundation||Oscar Lilli Lamms Minne Foundation||Langmanska kulturfonden||Lars Hiertas Minne Foundation||IKERBASQUE, Basque Foundation for Science||CBR-SSF||Angpanneforening Research Foundation||Ciencia program of the Ministerio da Educacao e Ciencia (MEC, Lisbon, Portugal)||

Available from: 2012-09-25 Created: 2012-09-24 Last updated: 2015-03-24

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