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Long-term Clinical Outcome After Lyme Neuroborreliosis in Childhood
Falun General Hospital, Sweden Centre Clin Research Dalarna, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Norrköping.
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
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2012 (English)In: Pediatrics, ISSN 0031-4005, E-ISSN 1098-4275, Vol. 130, no 2, 262-269 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To determine long-term clinical outcome in children with confirmed Lyme neuroborreliosis (LNB) and to evaluate persistent subjective symptoms compared with a control group. less thanbrgreater than less thanbrgreater thanMETHODS: After a median of 5 years, 84 children with confirmed LNB underwent a neurologic re-examination, including a questionnaire. Medical records were analyzed, and a control group (n = 84) was included. less thanbrgreater than less thanbrgreater thanRESULTS: The total recovery rate was 73% (n = 61). Objective neurologic findings, defined as "definite sequelae," were found in 16 patients (19%). The majority of these children had persistent facial nerve palsy (n = 11), but other motor or sensory deficits occurred (n = 5). Neurologic signs and/or symptoms defined as "possible sequelae" were found in another 7 patients (8%), mainly of sensory character. Nonspecific subjective symptoms were reported by 35 patients (42%) and 32 controls (38%) (nonsignificant). Affected daily activities or school performance were reported to the same extent in both groups (23% vs 20%, nonsignificant). less thanbrgreater than less thanbrgreater thanCONCLUSIONS: The long-term clinical recovery rate was 73% in children with confirmed LNB. Persistent facial nerve palsy occurred in 13%, whereas other motor or sensory deficits were found in another 14%. Neurologic deficits did not affect daily activities or school performance more often among patients than controls and should be considered as mild. Furthermore, nonspecific subjective symptoms such as headache, fatigue, or memory or concentration problems were reported as often among patients as controls and should not be considered as sequelae after LNB.

Place, publisher, year, edition, pages
American Academy of Pediatrics , 2012. Vol. 130, no 2, 262-269 p.
Keyword [en]
Lyme borreliosis, neuroborreliosis, children, clinical outcome, sequelae, facial nerve palsy, persistent symptoms
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-81832DOI: 10.1542/peds.2011-3719ISI: 000307123000046OAI: oai:DiVA.org:liu-81832DiVA: diva2:556598
Note

Funding Agencies|Research Council in Southeast Sweden (FORSS)||County Council in Ostergotland||Center of Clinical Research in Dalarna (CKF)||Swedish Society of Medicine||Lions Foundation||Holmia Foundation||

Available from: 2012-09-25 Created: 2012-09-24 Last updated: 2017-12-07

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Nordwall, MariaVrethem, MagnusÖdkvist, LarsForsberg, Pia

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Infectious DiseasesFaculty of Health SciencesPediatricsDepartment of Paediatrics in NorrköpingNeurologyDepartment of NeurologyOto-Rhiono-Laryngology and Head & Neck SurgeryDepartment of ENT - Head and Neck Surgery UHLDepartment of Infectious Diseases in Östergötland
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