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Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia
Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.
Uppsala University, Sweden Linneaus University, Sweden .
Linneaus University, Sweden .
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2012 (English)In: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ISSN 1046-7408, Vol. 68, no 3, 258-270 p.Article in journal (Refereed) Published
Abstract [en]

Problem Although preeclampsia has been associated with inflammation, coagulation, and angiogenesis, their correlation and relative contribution are unknown. Method of Study About 114 women with preeclampsia, 31 with early onset (EOP) and 83 with late onset preeclampsia (LOP), and 100 normal pregnant controls were included. A broad panel of 32 biomarkers reflecting coagulation, inflammation, and angiogenesis was analyzed. Results Preeclampsia was associated with decreased antithrombin, IL-4 and placental growth factor levels and with increased C3a, pentraxin-3, and sFlt-1 levels, with more marked differences in the EOP group. The Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in the preeclampsia and EOP group than in controls, respectively. No correlations between the biomarkers were found in preeclampsia. Multivariate logistic regression tests confirmed the results. Conclusions Cytokines, chemokines and complement activation seem to be part of a Th1-like inflammatory reaction in preeclampsia, most pronounced in EOP, where chemokines may be more useful than cytokines as biomarkers. Biomarkers were not correlated suggesting partly independent or in time separated mechanisms.

Place, publisher, year, edition, pages
John Wiley and Sons , 2012. Vol. 68, no 3, 258-270 p.
Keyword [en]
preeclampsia, coagulation, inflammation, angiogenesis, chemokines, cytokines and early onset preeclampsia
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-81815DOI: 10.1111/j.1600-0897.2012.01158.xISI: 000307440300012OAI: diva2:556711

Funding Agencies|FORSS (Medical Research Council of Southeast Sweden)||Futurum (the Research department of County of Jonkoping)||Swedish Research Council|2007-15809-48800-58|Linneaus University (Sweden)||

Available from: 2012-09-26 Created: 2012-09-24 Last updated: 2013-11-07

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Boij, RolandSvensson, JuditLindahl, TomasBerg, GöranErnerudh, JanJenmalm, MariaMatthiesen, Leif
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Obstetrics and gynecologyFaculty of Health SciencesClinical ImmunologyClinical ChemistryDepartment of Clinical ChemistryDepartment of Gynaecology and Obstetrics in LinköpingDepartment of Clinical Immunology and Transfusion MedicinePediatrics
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