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Phylogenetically diverse TT virus viremia among pregnant women
Karolinska Institutet and Karolinska University Hospital, Stockholm.
Lund University, Malmö.
Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, The Institute of Technology.
Karolinska Institutet and Karolinska University Hospital, Stockholm.
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2012 (English)In: Virology, ISSN 0042-6822, EISSN 1096-0341, Vol. 432, no 2, 427-434 p.Article in journal (Refereed) Published
Abstract [en]

Infections during pregnancy have been suggested to be involved in childhood leukemias. We used high-throughput sequencing to describe the viruses most readily detectable in serum samples of pregnantwomen. Serum DNA of 112 mothers to leukemic children was amplified using whole genome amplification. Sequencing identified one TTvirus (TTV) isolate belonging to a known type and two putatively new TTVs. For 22 mothers, we also performed TTV amplification by general primer PCR before sequencing. This detected 39 TTVs, two of which were identical to the TTVs found after whole genome amplification.

Altogether, we found 40 TTV isolates, 29 of which were putatively new types (similarities ranging from 89% to 69%). In conclusion, high throughput sequencing is useful to describe the known or unknown viruses that are present in serum samples of pregnantwomen.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 432, no 2, 427-434 p.
Keyword [en]
Childhood leukemia; TTvirus; High throughput sequencing
National Category
Bioinformatics and Systems Biology
URN: urn:nbn:se:liu:diva-81957DOI: 10.1016/j.virol.2012.06.022ISI: 000308121600021OAI: diva2:556849

funding agencies|European Union Network of Excellence Cancer Control using Population-based Registries and Biobanks||Swedish Cancer Society||Swedish Research Council||Karolinska Institutet||

Available from: 2012-09-26 Created: 2012-09-26 Last updated: 2012-10-05

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