Investigating protein variants using structural calculation techniques
2012 (English)In: Homology Modeling: Methods and Protocols / [ed] Andrew J. W. Orry and Ruben Abagyan, Springer, 2012, Vol. 857, 313-330 p.Chapter in book (Other academic)
Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. In, Homology Modeling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Homology Modeling: Methods and Protocols guides scientists in the available homology modeling methods.
Place, publisher, year, edition, pages
Springer, 2012. Vol. 857, 313-330 p.
, Methods in Molecular Biology, ISSN 1064-3745, EISSN 1940-6029 ; 857
Sequence alignment (Bioinformatics), Life sciences, Biochemistry, Protein Science, Protein Structure
Bioinformatics and Systems Biology
IdentifiersURN: urn:nbn:se:liu:diva-81961DOI: 10.1007/978-1-61779-588-6_14ISBN: 978-1-61779-587-9ISBN: e.978-1-61779-588-6OAI: oai:DiVA.org:liu-81961DiVA: diva2:556867