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CD38: a NAADP degrading enzyme
University Medical Centre Hamburg-Eppendorf, Germany.
University Medical Centre Hamburg-Eppendorf, Germany.
University Medical Centre Hamburg-Eppendorf, Germany.
University Medical Centre Hamburg-Eppendorf, Germany.
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2011 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 585, no 22, 3544-3548 p.Article in journal (Refereed) Published
Abstract [en]

The role of the multifunctional enzyme CD38 in formation of the Ca2+-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADPdegrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.

Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 585, no 22, 3544-3548 p.
Keyword [en]
Calcium signalling; NAADP; CD38; Jurkat T lymphocyte
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-81987DOI: 10.1016/j.febslet.2011.10.017OAI: oai:DiVA.org:liu-81987DiVA: diva2:557233
Available from: 2012-09-27 Created: 2012-09-27 Last updated: 2017-12-07

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Bruhn, Sören

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