CD38: a NAADP degrading enzyme
2011 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 585, no 22, 3544-3548 p.Article in journal (Refereed) Published
The role of the multifunctional enzyme CD38 in formation of the Ca2+-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADPdegrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells.
Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 585, no 22, 3544-3548 p.
Calcium signalling; NAADP; CD38; Jurkat T lymphocyte
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-81987DOI: 10.1016/j.febslet.2011.10.017OAI: oai:DiVA.org:liu-81987DiVA: diva2:557233