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Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates
Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-5582-140X
2012 (English)In: Biochemical Society Transactions, ISSN 0300-5127, E-ISSN 1470-8752, Vol. 40, 704-710 p.Article in journal (Refereed) Published
Abstract [en]

The deposition of protein aggregates in various parts of our body gives rise to several devastating diseases, and the development of probes for the selective detection of aggregated proteins is crucial to advance our understanding of the pathogenesis underlying these diseases. LCPs (luminescent conjugated polythiophenes) are fluorescent probes that bind selectively to protein aggregates. The conjugated thiophene backbone is flexible and offers a connection between the conformation and the emission properties, hence binding of LCPs gives the molecule a spectral fingerprint. The present review covers the utilization of LCPs to study the heterogeneity of protein aggregates. It emphasizes specifically the introduction of well-defined probes called LCOs (luminescent conjugated oligothiophenes) and reports how these molecules can be used for real-time in vivo imaging of cerebral plaques as well as for spectral discrimination of protein aggregates and detection of early species in the fibrillation pathway of amyloid beta-peptide.

Place, publisher, year, edition, pages
Portland Press , 2012. Vol. 40, 704-710 p.
Keyword [en]
amyloid beta-peptide (A beta), conjugated polymer, luminescent conjugated oligothiophene, luminescent conjugated polythiophene, thioflavin T
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-84360DOI: 10.1042/BST20120009ISI: 000307431700020OAI: oai:DiVA.org:liu-84360DiVA: diva2:558774
Note

Funding Agencies|Swedish Foundation for Strategic Research||European Research Council||

Available from: 2012-10-05 Created: 2012-10-05 Last updated: 2017-12-07

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Klingstedt, TheréseNilsson, Peter

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