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Scale-up of cell culture bioreactors using biomechatronic design
Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, The Institute of Technology.
Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, The Institute of Technology.
2012 (English)In: Biotechnology Journal, ISSN 1860-6768, Vol. 7, no 8, 1026-1039 p.Article in journal (Refereed) Published
Abstract [en]

Scale-up of cell culture bioreactors is a challenging engineering work that requires wide competence in cell biology, mechanical engineering and bioprocess design. In this article, a new approach for cell culture bioreactor scale-up is suggested that is based on biomechatronic design methodology. The approach differs from traditional biochemical engineering methodology by applying a sequential design procedure where the needs of the users and alternative design solutions are systematically analysed. The procedure is based on the biological and technical functions of the scaled-up bioreactor that are derived in functional maps, concept generation charts and scoring and interaction matrices. Basic reactor engineering properties, such as mass and heat transfer and kinetics are integrated in the procedure. The methodology results in the generation of alternative design solutions that are thoroughly ranked with help of the user needs. Examples from monoclonal antibodies and recombinant protein production illuminate the steps of the procedure. The methodology provides engineering teams with additional tools that can significantly facilitate the design of new production methods for cell culture processes.

Place, publisher, year, edition, pages
Wiley-VCH Verlag Berlin , 2012. Vol. 7, no 8, 1026-1039 p.
Keyword [en]
Biomechatronic design, Bioreactor engineering, Mammalian cell culture, Scaling-up, Systematic design
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-84358DOI: 10.1002/biot.201100463ISI: 000307218400016OAI: diva2:558775
Available from: 2012-10-05 Created: 2012-10-05 Last updated: 2012-10-30

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Mandenius, Carl-FredrikBjörkman, Mats
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