liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Personalized treatment of adult depression: medication, psychotherapy, or both? A systematic review
Vrije University, Amsterdam, the Netherlands.
University of Pittsburgh School of Medicine, Pennsylvania, USA.
Vrije University, Amsterdam, the Netherlands.
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Show others and affiliations
2012 (English)In: Depression and anxiety (Print), ISSN 1091-4269, E-ISSN 1520-6394, Vol. 29, no 10, 855-864 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Personalized medicine aims to identify which characteristics of an individual predict the outcome of a specific treatment, in order to get a better match between the individual and the treatment received. We conducted a systematic review and meta-analysis of randomized trials comparing two treatments directly in a group of patients with a specific characteristic.

METHODS: We searched relevant studies from bibliographical databases and included trials comparing (1) medication with psychotherapy, (2) medication with combined treatment, and (3) psychotherapy with combined treatment, in specific target groups (a) with a predefined sociodemographic characteristic, (b) a specific type of depression, (c) a comorbid mental or somatic disorder, or (d) from a specific setting (outpatients, primary care).

RESULTS: We included 52 studies with 4,734 depressed patients. In these studies, 20 characteristics of the target groups were examined. The results showed that medication is probably the best treatment for dysthymia, and combined treatments are more effective in depressed outpatients, as well as in depressed older adults. However, in order to examine the 20 characteristics in the three categories of comparisons, 254 studies would be needed for having sufficient statistical power to show an effect size of g = 0.5. Currently, only 20.1% of these studies have been conducted.

CONCLUSIONS: Although a considerable number of studies have compared medication, psychotherapy, and combined treatments, and some preliminary results are useful for deciding which treatment is best for which patient, the development of personalized treatment of depression has only just begun.

Place, publisher, year, edition, pages
John Wiley & Sons, 2012. Vol. 29, no 10, 855-864 p.
National Category
Psychology Psychiatry
URN: urn:nbn:se:liu:diva-84445DOI: 10.1002/da.21985ISI: 000309394600004PubMedID: 22815247OAI: diva2:559180
Available from: 2012-10-08 Created: 2012-10-08 Last updated: 2014-11-28

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Andersson, Gerhard
By organisation
PsychologyFaculty of Arts and Sciences
In the same journal
Depression and anxiety (Print)

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 192 hits
ReferencesLink to record
Permanent link

Direct link