Intranasal versus intravenous administration of midazolam to children undergoing small bowel biopsy
1995 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 84, no 12, 1429-1431 p.Article in journal (Refereed) Published
Sixty-three children under the age of 9 years were randomized to receive intravenous (group A, n= 33) or intranasal (group B, n= 30) midazolam as sedation for small bowel biopsy. Mean doses of midazolam given to produce adequate sedation were 0.31 mg (kg body weight)−1 in group A and 0.34 mg (kg body weight)−1 in group B (NS). Four children in group A and 10 children in group B required additional doses to maintain adequate sedation throughout the biopsy procedure (p <0.05). There was no significant difference between the groups regarding the median procedure time (7 min in group A, 8.5 min in group B) or median fluoroscopy time (5 s in group A, 4 s in group B). All children in group B showed signs of discomfort from the nose when given midazolam intranasally. In conclusion, this study indicates that intravenous administration of midazolam is preferable to the intranasal route.
Place, publisher, year, edition, pages
1995. Vol. 84, no 12, 1429-1431 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-84484DOI: 10.1111/j.1651-2227.1995.tb13582.xOAI: oai:DiVA.org:liu-84484DiVA: diva2:559519