liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Quantification of alpha-synuclein in cerebrospinal fluid
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2012 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

To date there is no accepted clinical diagnostic test for Parkinson's disease (PD) based on biochemical analyses of blood or cerebrospinal uid. Currently, diagnosis, measurement of disease progression and response to therapeutic intervention are based on clinical observation, but the rst neuronal dysfunction precede the earliest recognition of symptom by at least 5 - 10 years. A potential diagnostic biomarker is oligomeric alpha-synuclein which in recent papers have reported a signicant quantitative dierence between PD and controls. In this master thesis, a method for measuring oligomeric levels of alpha-synuclein is presented together with a monomeric measuring commercial kit used to measure alpha-synuclein in a preclinical model of PD. A signicant dierence of monomeric levels could be detected between two weeks and four weeks post injection of a vector containing the gene for human alpha-synuclein, no signicant dierence between four and eight weeks was found.

Place, publisher, year, edition, pages
2012. , 40 p.
Keyword [en]
alpha-synuclein parkinson cerebrospinal fluid biomarker
National Category
Pharmaceutical Biotechnology
URN: urn:nbn:se:liu:diva-84598ISRN: LiTH-IFM-A-EX--12/2591--SEOAI: diva2:560511
External cooperation
Subject / course
Available from: 2012-11-20 Created: 2012-10-15 Last updated: 2012-11-20Bibliographically approved

Open Access in DiVA

Quantification of alpha-synuclein in cererospinal fluid(3440 kB)297 downloads
File information
File name FULLTEXT01.pdfFile size 3440 kBChecksum SHA-512
Type fulltextMimetype application/pdf

By organisation
Department of Physics, Chemistry and BiologyThe Institute of Technology
Pharmaceutical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar
Total: 297 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 121 hits
ReferencesLink to record
Permanent link

Direct link