Effects of the GABA agonists baclofen and THIP on long-term compensation in hemilabyrinthectomised rats
1998 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 795, no 1-2, 307-311 p.Article in journal (Refereed) Published
Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8–12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer program, demonstrating an asymmetry. Systemic single administration of the GABAB agonist baclofen caused a dose-related temporary rebalancing of the compensatory eye movements to the LS and the IS. At an optimal dose of 14 μmol/kg b.wt symmetry was achieved by excitation of eye movements during rotation to the LS and depression during rotation to the IS. Administration of the GABAA agonist THIP did not obviously reduce the asymmetry. It is suggested that stimulation of GABAB receptors modifies the tonic imbalance between the bilateral vestibular nuclei and/or the central processing of the input from the peripheral sensory organs.
Place, publisher, year, edition, pages
1998. Vol. 795, no 1-2, 307-311 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-84752DOI: 10.1016/S0006-8993(98)00329-1OAI: oai:DiVA.org:liu-84752DiVA: diva2:561518