liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Maternal serum levels of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to body weight and composition of mother and infant
Linköping University, Department of Biomedicine and Surgery, Nutrition. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedicine and Surgery, Nutrition. Linköping University, Faculty of Health Sciences.
Unit for Endocrinology and Diabetes, Karolinska Institutet, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Linköping University, Department of Biomedicine and Surgery, Nutrition. Linköping University, Faculty of Health Sciences.
Show others and affiliations
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Objectives: To investigate the following relationships: 1) maternal body weight and composition versus insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 in maternal serum before and during pregnancy, and 2) IGF-I and IGFBP-1 in maternal serum during pregnancy versus infant birth weight, body composition and ponderal index.

Study design: Serum was collected from 23 healthy women before pregnancy, and in weeks 14, 32 and 35 of pregnancy. On these occasions maternal body weight and composition were assessed. Weight, length and body composition of the newborn were measured. Linear and multiple linear regression analyses were applied.

Results: Women with the lowest body weight and body fat content had the largest decreases in IGF-I in early pregnancy. During pregnancy maternal fat-free body weight was positively related to IGF-I, whereas body fat was inversely related to IGFBP-1. Maternal body weight before pregnancy and IGF-I in week 14 of gestation explained 47 % of the variation in birth weight.

Conclusion: The maternal IGF-system may be a mediator of the effect of maternal nutritional status on fetal growth.

National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-85046OAI: oai:DiVA.org:liu-85046DiVA: diva2:563852
Available from: 2012-10-31 Created: 2012-10-31 Last updated: 2012-10-31
In thesis
1. Nutritional status before and during pregnancy in relation to the maternal insulin-like growth factor-system and health related variables in the offspring
Open this publication in new window or tab >>Nutritional status before and during pregnancy in relation to the maternal insulin-like growth factor-system and health related variables in the offspring
2004 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Adequate fetal growth is of importance for health in adulthood. Maternal nutritional status has been suggested to be one major factor influencing fetal development. The nature of how the mother's nutritional status and her metabolic, endocrine and physiological adaptations to pregnancy interact and how these interactions affect fetal growth is unclear. The insulin-like growth factor (IOF)-system has been suggested to be one mediator between maternal nutritional status and fetal growth. Impaired fetal growth may have life-long effects, but little is known about the possibilities to ameliorate intrauterine perturbations postnatally. Oxytocin, an anti-stress hormone, was used as a model to study such possibilities.

The aims were: to measure serum levels of IGF-I, IGF-II, IGF-binding protein (IGFBP)-1, IGFBP-3 and protease activity against IOFBP-3 in healthy women before, during and after pregnancy; to study the relationships regarding maternal body weight and composition before and during pregnancy versus components of the maternal IGF-system in serum in healthy women; to study the relationships regarding components of the maternal IGF-system in serum versus infant birth weight; to measure the expression of mRNA for IGF-I and IGF-II in different tissues in guinea pigs and to study how these expressions are altered by gestation and food restriction; to study long-term effects of maternal food restriction during gestation on health related variables in adult rat offspring; to study long-term effects of early postnatal treatment of oxytocin in the adult rat offspring.

Healthy women were studied before pregnancy, in weeks 8, 14, 20, 32, 35 of pregnancy and 2 weeks postpartum. Body weight, body composition and serum levels of IGF-I, IGF-II, IGFBP-1, IGFBP-3 and protease activity against IOFBP-3 were measured. Infant body weight and length at birth were obtained from hospital records. The amounts of mRNA for IGF-I and IGF-II in the liver, adipose tissues, muscles, spleen, uterus and placenta were measured in virginal and pregnant guinea pigs, being either ad libitum fed or food restricted. Rat dams were either ad libitum fed or food restricted during gestation. Their offspring received oxytocin or NaCI at day 1-14 of age. Blood pressure, plasma levels of corticosterone, IGF-1, IGFBP-1, and reproductive performance were measured in the adult offspring.

All of the studied components of the IGF-system in serum underwent changes during pregnancy. The levels of IGF-1 were reduced in early pregnancy compared to before conception. The lower the body weight or the less amount of body fat before pregnancy, the larger the decrease in IGF-I in early pregnancy. The combination of body weight before pregnancy and the serum level of IGF-I in early pregnancy explained as much as 47 % of the variation in birth weight, indicating that the higher the maternal body weight before pregnancy and the lower the level of IGF-I in early pregnancy, the heavier the infant. From week 20 of pregnancy, maternal levels of IGFBP-I were negatively correlated to birth weight. In late pregnancy, the abundance of IGFBP-I and protease activity in serum together explained 35% of the variation in birth weight, indicating that the lower the IGFBP-I and the higher the protease activity, the higher the birth weight. In guinea pigs, mRNA for IGF-I was expressed in high amounts in adipose tissue and liver, whereas mRNA for IGF-II were highly expressed in placenta and liver. The expression of IGF-I was in general unaffected by food restriction, but doubled during gestation, whereas the expression of IGF-II in the placenta was decreased by food restriction and increased in the liver by gestation. Maternal food restriction during gestation caused increased levels of corticosterone, IGF-I and IGFBP-I, but no elevation in blood pressure, in adult offspring. Early postnatal oxytocin treatment decreased blood pressure and corticosterone, whereas the influence on reproductive performance was dependent on the nutritional status of their dams and the current nutritional experience in adulthood.

In conclusion, this thesis confirms that the IGF-system may be one factor mediating the effects of maternal nutritional status on fetal growth. It also supports the suggestion that IGFBP-I in maternal serum may be used as a marker of infant birth weight. Adipose tissue was shown to produce high amounts of IGF-I, indicating endocrine functions during gestation. Postnatal oxytocin treatment ameliorated some of the adverse effects in adult offspring, induced by maternal food restriction.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2004. 66 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 860
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-23979 (URN)3530 (Local ID)91-7373-835-2 (ISBN)3530 (Archive number)3530 (OAI)
Public defence
2004-10-08, Hälsans Hus, Hälsouniversitetet, Linköping, 13:00 (Swedish)
Opponent
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2012-10-31Bibliographically approved

Open Access in DiVA

No full text

Authority records BETA

Olausson, HannaLöf, MarieForsum, ElisabetSohlström, Annica

Search in DiVA

By author/editor
Olausson, HannaLöf, MarieForsum, ElisabetSohlström, Annica
By organisation
NutritionFaculty of Health Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 22 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf