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LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
Hong Kong University of Science and Technology, Peoples R China .
University of Hong Kong, Peoples R China .
University of Hong Kong, Peoples R China .
University of Helsinki, Finland University of Helsinki, Finland .
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2012 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 325, no 1, 89-98 p.Article in journal (Refereed) Published
Abstract [en]

This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 325, no 1, 89-98 p.
Keyword [en]
Latent transforming growth factor beta binding protein 2 (LTBP-2), Nasopharyngeal carcinoma (NPC), Anti-angiogenesis, Tumor suppression, Tumor cell dormancy, Metastatic growth
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-84878DOI: 10.1016/j.canlet.2012.06.005ISI: 000308781600011OAI: diva2:564145

Funding Agencies|University Grants Council|AoE/M-06/08|Finnish Cancer Foundation||Swedish Cancer Society||Swedish Research Council||Swedish Institute||Karolinska Institute||

Available from: 2012-11-01 Created: 2012-10-26 Last updated: 2012-11-01

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Department of Clinical and Experimental MedicineFaculty of Health Sciences
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Cancer Letters
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