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Fabrication of conducting electrospun nanofibers scaffold for three-dimensional cells culture
National Institute Mat Science, Japan GJ University of Science and Technology, India .
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, The Institute of Technology.
National Institute Mat Science, Japan .
National Institute Mat Science, Japan .
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2012 (English)In: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 51, no 4, 627-631 p.Article in journal (Refereed) Published
Abstract [en]

Electrospinning is a versatile method to fabricate nanofibers of a range of polymeric and composite materials suitable as scaffolds for tissue engineering applications. In this study, we report the fabrication and characterization of polyaniline-carbon nanotube/poly(N-isopropyl acrylamide-co-methacrylic acid) (PANI-CNT/PNIPAm-co-MAA) composite nanofibers and PNIPAm-co-MAA nanofibers suitable as a three-dimensional (3D) conducting smart tissue scaffold using electrospinning. The chemical structure of the resulting nanofibers was characterized with FUR and H-1 NMR spectroscopy. The surface morphology and average diameter of the nanofibers were observed by SEM. Cellular response of the nanofibers was studied with mice L929 fibroblasts. Cell viability was checked on 7th day of cell culture by double staining the cells with calcein-AM and PI dye. PANI-CNT/PNIPAm-co-MAA composite nanofibers were shown the highest cell growth and cell viability as compared to PNIPAm-co-MAA nanofibers. Cell viability in the composite nanofibers was obtained in order of 98% that indicates the composite nanofibers provide a better environment as a 3D scaffold for the cell proliferation and attachment suitable for tissue engineering applications.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 51, no 4, 627-631 p.
Keyword [en]
Polyaniline, Carbon nanotube, Thermoresponsive polymers, Scaffolds and tissue engineering
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-85080DOI: 10.1016/j.ijbiomac.2012.06.014ISI: 000309310500040OAI: diva2:564635

Funding Agencies|European Commission|PIIF-GA-20 09-254955|JSPS||JST-CREST||MEXT||NIMS|FY2011|

Available from: 2012-11-02 Created: 2012-11-02 Last updated: 2012-11-02

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Tiwari, Ashutosh
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Biosensors and BioelectronicsThe Institute of Technology
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