Stress and immune response in patients exposed to intra- or postoperative music: a randomised controlled trial
(English)Manuscript (preprint) (Other academic)
This randomised controlled trial was designed to evaluate whether intra- or postoperative music could influence stress and immune response during and after general anaesthesia and also if there was a different response between patients exposed to music intraoperatively or postoperatively. Seventy-five patients undergoing open hernia repair as day care surgery were randomly allocated to three groups: intraoperative music (IM), postoperative music (PM) and silence i.e. control group. The anaesthesia and postoperative analgesia were standardised and the same surgeon performed all the operations. Stress response was assessed during and after surgery by determining the plasma cortisol and blood glucose levels. Immune function was evaluated by studying immuuoglobulin A (IgA) levels. Patients' postoperative pain, anxiety, blood pressure, heart rate and oxygen saturation were also studied as stress markers. The results showed that there were significant differences between the PM group and the control group with regard to more marked decreased levels of cortisol and less marked increased glucose levels after 2 hours in the postanaesthesia care unit (PACU). The PM group also rated less anxiety and the IM and PM group rated less pain after 1 hour in the PACU compared with the control group. There was no difference in IgA, blood pressure, heart rate and oxygen saturation between the groups. This study indicating that postoperative music decreases patients' stress response with regard to s-cortisol, b-glucose and anxiety. Music therapy also has an influence intra- or postoperatively on postoperative pain intensity, but not on immune function as assessed by IgA.
Music, general anaesthesia, intraoperative, postoperative, cortisol, glucose, IgA, anxiety, pain
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-85128OAI: oai:DiVA.org:liu-85128DiVA: diva2:565066