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A patient with both narcolepsy and multiple sclerosis in association with Pandemrix vaccination
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
Gothenburg University, Sweden .
Ryhov County Hospital, Sweden .
2012 (English)In: Journal of the Neurological Sciences, ISSN 0022-510X, E-ISSN 1878-5883, Vol. 321, no 1-2, 89-91 p.Article in journal (Refereed) Published
Abstract [en]

Narcolepsy with cataplexy is caused by a selective loss of hypocretin-producing neurons, but symptomatic narcolepsy can also result from hypothalamic and brainstem lesions caused by multiple sclerosis (MS). We report a previously healthy man who developed clinical and laboratory verified narcolepsy without having any indication of hypothalamic lesions and MS after vaccination against the influenza H1N1 with Pandemrix. HLA typing showed both DRB1*15:01, associated with MS and DQB1*06:02, associated with narcolepsy. The genetic susceptibility in this patient makes it tempting to speculate upon an immune-mediated mechanism and a common etiology for both diseases in this patient.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 321, no 1-2, 89-91 p.
Keyword [en]
Pandemrix, Vaccination, Narcolepsy, Multiple sclerosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-85194DOI: 10.1016/j.jns.2012.07.025ISI: 000309570000016OAI: diva2:566681

Funding Agencies|Biogen Idec||

Available from: 2012-11-09 Created: 2012-11-09 Last updated: 2012-11-09

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Vrethem, Magnus
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