liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Luftprovtagning samt analys av mono- och diisocyanater
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2012 (Swedish)Independent thesis Basic level (university diploma), 10,5 credits / 16 HE creditsStudent thesisAlternative title
Air sampling and analysis of mono- and diisocyanates (English)
Abstract [en]

When exposed to them, isocyanates can induce serious injuries in the respiratory tract and irritation on the skin and in the eyes. They are therefore interesting from the point of view of occupational health. The purpose of this thesis was to collect isocyanates in air with impinger-filter samplers and solvent free samplers. Furthermore the isocyanates were to be analyzed with liquid chromatography-mass spectrometry. The solvent free sampler consists of a polypropylene tube and filter holder fitted with glass fiber filters impregnated with derivatization reagent, coupled with a pump. The impinger-filter sampler was made out of an impinger flask, containing a derivatization solution, coupled in series with a filter holder and a pump. Di-n-butylamine was used as derivatization reagent in both samplers to stabilize the reactive isocyanates and to enable mass spectrometric detection. The solvent free sampler is highly advantageous because of its user friendliness during field measurements, as opposed to the impinger-filter method. An exposure chamber, equipped with two interior fans to ensure good circulation, was used to generate an atmosphere containing isocyanates.

Analyzing the isocyanate-DBA derivates with LC-MS/MS worked very well and the method made it possible to detect isocyanate levels below 1 ng/mL. During quantification of isocyanates a standard curve with concentrations from 1 to 1000 ng/mL was used. Detection of isocyanate levels as low as one fifth of the limit value of some isocyanates was found to be possible, which would indicate that the methods are sensitive. Even though the solvent free sampler worked, the impinger-filter sampler was found to be more effective in collecting isocyanates. The coefficient of variation calculated from concentrations of isocyanates from the solvent free sampler varied between 0-35 %. The reason for this might be due to the fact that an optimized extraction method had not been tried out within the time limit of this project. Questions, identified during this thesis work, need to be answered before being able to obtain reliable results from field measurements with the solvent free sampler.

Place, publisher, year, edition, pages
2012. , 24 p.
Keyword [sv]
Isocyanater, impinger, luftprovtagning, torr provtagning, LC-MS/MS
National Category
Analytical Chemistry
URN: urn:nbn:se:liu:diva-85247ISRN: LITH-IFM-G-EX—12/2606—SEOAI: diva2:567671
External cooperation
Arbets- och Miljömedicin i Linköping
Subject / course
Chemical Engineering
Physics, Chemistry, Mathematics
Available from: 2012-11-14 Created: 2012-11-13 Last updated: 2012-11-14Bibliographically approved

Open Access in DiVA

fulltext(935 kB)262 downloads
File information
File name FULLTEXT01.pdfFile size 935 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Komorowska, Marta
By organisation
Department of Physics, Chemistry and BiologyThe Institute of Technology
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 262 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 167 hits
ReferencesLink to record
Permanent link

Direct link