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Healthy individuals immune response to the Bulgarian Crimean-Congo hemorrhagic fever virus vaccine
Swedish Institute Communicable Disease Control, Sweden .
Swedish Institute Communicable Disease Control, Sweden Karolinska Institute, Sweden .
Aristotle University of Thessaloniki, Greece .
National Centre Infect and Parasit Disease, Bulgaria .
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2012 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 30, no 44, 6225-6229 p.Article in journal (Refereed) Published
Abstract [en]

Crimean-Congo hemorrhagic fever virus (CCHFV) poses a great threat to public health due to its high mortality and transmission rate and wide geographical distribution. There is currently no specific antiviral therapy for CCHF. This study provides the first in-depth analysis of the cellular and humoral immune response in healthy individuals following injection of inactivated Bulgarian vaccine, the only CCHFV vaccine available at present. Vaccinated individuals developed robust, anti-CCHFV-specific T-cell activity as measured by IFN-gamma ELISpot assay. The frequency of IFN-gamma secreting T-cells was 10-fold higher in individuals after vaccination with four doses than after one single dose. High levels of CCHFV antibodies were observed following the first dose, but repeated doses were required to achieve antibodies with neutralizing activity against CCHFV. However, the neutralizing activity in these groups was low.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 30, no 44, 6225-6229 p.
Keyword [en]
Crimean-Congo hemorrahgic fever, Vaccine, T-cell response, Neutralising antibodies
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-85301DOI: 10.1016/j.vaccine.2012.08.003ISI: 000309616900001OAI: diva2:570292

Funding Agencies|European Commission|260427|

Available from: 2012-11-19 Created: 2012-11-15 Last updated: 2012-11-19

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Department of Clinical and Experimental MedicineFaculty of Health Sciences
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