Concentration Ratios of Methamphetamine to Amphetamine in Blood Can Help to Distinguish Use of Methamphetamine from Various Mixtures of the Two Stimulants
2012 (English)In: Journal of Analytical Toxicology, ISSN 0146-4760, Vol. 36, no 9, 634-637 p.Article in journal (Refereed) Published
Using a forensic toxicology database, the authors investigated cases of driving under the influence of drugs (DUID) if methamphetamine (MA) was identified in the blood samples (N 9,310). The concentrations of MA and amphetamine (AM) in blood were determined after liquidliquid extraction by gas chromatographymass spectrometry at limits of quantitation of 0.03 mg/L for both stimulants. In 814 cases, AM was negative in blood and MA was positive at mean (median) and highest concentrations of 0.19 mg/L (0.11 mg/L) and 3.4 mg/L, respectively. Both amines were present in blood in 8,496 cases at concentrations of 0.54 mg/L (0.35 mg/L) and 10.4 mg/L for AM and 0.41 mg/L (0.22 mg/L) and 5.6 mg/L for MA. However, the correlation between AM and MA was low and insignificant (r 0.13) in the whole material. The coefficient of correlation increased to r 0.41 (P 0.001) when the MA/AM concentration ratio was 1. When MA/AM ratios were selected at intervals of 1.0 (e.g., 3.0 and 4.0 up to 9.0 and 10.0), the correlation between AM and MA was r 0.99 (P 0.001). Such cases represent the use of MA without contamination from AM, and the mean (median) and highest concentrations of this secondary amine in blood of DUID suspects were 0.72 mg/L (0.56 mg/L) and 4.2 mg/L, respectively.
Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy F , 2012. Vol. 36, no 9, 634-637 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-85628DOI: 10.1093/jat/bks075ISI: 000309924300006OAI: oai:DiVA.org:liu-85628DiVA: diva2:572058