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G/A polymorphism in intronic sequence affects the processing of MAO-B gene in patients with Parkinson disease
Vilnius University, Lithuania .
Vilnius University, Lithuania .
Vilnius University, Lithuania .
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
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2012 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 586, no 20, 3698-3704 p.Article in journal (Refereed) Published
Abstract [en]

Monoamine oxidase B (MAO-B) plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Increased levels of MAO-B mRNA and enzymatic activity have been reported in platelets from patients with Parkinsons and Alzheimers diseases, however the triggers of enhanced mRNA levels are unknown. Our results demonstrate for the first time that G/A dimorphism in intron 13 sequence creates splicing enhancer thus stimulating intron 13 removal efficiency. The increased MAO-B protein levels might serve as a surrogate marker for - Parkinson disease.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 586, no 20, 3698-3704 p.
Keyword [en]
Monoamino oxidase B, Parkinson disease, Single nuclotide polymorphism (SNP), Pre-mRNA splicing, Splicesome, SR protein
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-85856DOI: 10.1016/j.febslet.2012.08.028ISI: 000310397200024OAI: oai:DiVA.org:liu-85856DiVA: diva2:573275
Note

Funding Agencies|Research Council of Lithuania|LIG-14/2010|

Available from: 2012-11-30 Created: 2012-11-30 Last updated: 2017-12-07

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Söderkvist, Peter

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