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Low-level mechanical stimulation is sufficient to improve tendon healing in rats
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
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2012 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 113, no 9, 1398-1402 p.Article in journal (Refereed) Published
Abstract [en]

Treatment of tendon injuries often involves immobilization. However, immobilization might not prevent mild involuntary isometric muscle contraction. The effect of weak forces on tendon healing is therefore of clinical interest. Studies of tendon healing with various methods for load reduction in rat Achilles tendon models show a consistent reduction in tendon strength by at least half, compared with voluntary cage activity. Unloading was not complete in any of these models, and the healing tendon was therefore still exposed to mild mechanical stimulation. By reducing the forces acting on the tendon even further, we now studied the effects of this mild stimulation. Rat Achilles tendons were transected and allowed to heal spontaneously under four different loading conditions: 1) normal cage activity; 2) calf muscle paralysis induced by botulinum toxin A (Botox); 3) tail suspension; 4) Botox and tail suspension, combined, to eliminate even mild stimulation. Healing was evaluated by mechanical testing after 8 days. Botox alone and suspension alone both reduced tendon callus size (transverse area), thereby impairing its strength compared with normal cage activity. The combination of Botox and suspension did not further reduce tendon callus size but drastically impaired the material properties of the tendon callus compared with each treatment alone. The peak force was only a fifth of that in the normal cage activity group. The results indicate that also the mild loading that occurs with either Botox or suspension alone stimulates tendon healing. This stimulation appears to affect mainly tissue quality, whereas stronger stimulation also increases callus size.

Place, publisher, year, edition, pages
American Physiological Society , 2012. Vol. 113, no 9, 1398-1402 p.
Keyword [en]
Achilles tendon, mechanical stress, wound healing, hindlimb unloading, immobilization
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-85847DOI: 10.1152/japplphysiol.00491.2012ISI: 000310649200007OAI: oai:DiVA.org:liu-85847DiVA: diva2:573290
Note

Funding Agencies|Swedish Research Council|2009-6725|Linkoping University||Ostergotland County Council||King Gustaf V and Queen Victoria Free Mason Foundation||Swedish National Center for Research in Sports||

Available from: 2012-11-30 Created: 2012-11-30 Last updated: 2017-12-07

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Andersson, ThereseEliasson, PernillaHammerman, MalinSandberg, OlofAspenberg, Per

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Andersson, ThereseEliasson, PernillaHammerman, MalinSandberg, OlofAspenberg, Per
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Department of Clinical and Experimental MedicineFaculty of Health SciencesOrthopaedicsDepartment of Orthopaedics in Linköping
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Journal of applied physiology
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