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An antithrombin III product containing biologically active hepatocyte growth factor may be beneficial in depp ulcer infections
PEAS Institute, Linköping, Sweden.
Linköping University, Department of Medical and Health Sciences, Nephrology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Infectious Diseases.
2012 (English)In: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 60, no 2, 478-486 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Widely studied for the past 20 years, hepatocyte growth factor (HGF) has been identified as a regenerative marker and an important factor in the development and healing of injuries. Antithrombin III (AT III) is a protein in the blood stream with anti-thrombotic and anti-inflammatory properties and has been used as an adjuvant treatment along with antibiotics in severe sepsis.

OBJECTIVE:

To study the content and properties of HGF in plasma-derived AT III products, and the regenerative effect in severe deep ulcer infections.

METHODS:

Commercial AT III products were analyzed for the presence and biological activity of HGF. One AT III product containing biologically active HGF was used to treat 18 cases of critical, deep ulcer infections scheduled for major invasive intervention. The patients were followed up for 6-60 months.

RESULTS:

The AT III products contained HGF with different biological activity. No adverse reactions were observed after local administration of AT III during the study or follow-up period. In 16 of 18 cases no surgical intervention was needed within the first 6 month of inclusion.

CONCLUSION:

AT III products containing biologically active HGF may contribute to regeneration and healing in severe deep ulcer infections which do not respond adequately to different combinations of antibiotics alone.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 60, no 2, 478-486 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-86279DOI: 10.1016/j.cyto.2012.05.023ISI: 000310494300024OAI: oai:DiVA.org:liu-86279DiVA: diva2:576221
Available from: 2012-12-12 Created: 2012-12-12 Last updated: 2017-12-07

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Almroth, GabrielBrudin, LarsNayeri, Fariba

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NephrologyFaculty of Health SciencesDepartment of NephrologyClinical PhysiologyInfectious DiseasesDepartment of Infectious Diseases
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