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PINCH expression and its clinicopathological significance in gastric adenocarcinoma
Hebei Medical University, Peoples R China.
Hebei Medical University, Peoples R China .
Hebei Medical University, Peoples R China .
Hebei Medical University, Peoples R China .
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2012 (English)In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 33, no 4, 171-178 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in patients with colorectal cancer. However, there is no study of PINCH in gastric cancer, therefore, the aim of this project was to investigate PINCH expression and its clinicopathological significance in gastric adenocarcinoma. less thanbrgreater than less thanbrgreater thanPatients and methods: PINCH expression was immunohistochemically examined in normal gastric mucous (n = 30) and gastric adenocarcinoma (n = 73), from gastric cancer patients. less thanbrgreater than less thanbrgreater thanResults: PINCH expression in the associated-stroma of gastric cancers was heterogeneous, and its positive rate (75%) was higher than that of normal gastric mucosa (43%, X-2 = 9.711, p = 0.002). The stronger staining was observed at the invasive edge of tumour when compared to the inner area of tumour. The rate of positive PINCH (88%) in the cases with lymph node metastasis was higher than that (52%) in the cases without metastasis (X-2 = 11.151, p = 0.001). PINCH expression was not correlated with patients gender, age, tumour size, differentiation and invasion depth (p andgt; 0.05). less thanbrgreater than less thanbrgreater thanConclusion: PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma.

Place, publisher, year, edition, pages
IOS Press , 2012. Vol. 33, no 4, 171-178 p.
Keyword [en]
PINCH, gastric adenocarcinoma, metastasis, immunohistochemistry
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-86392DOI: 10.3233/DMA-2012-0930ISI: 000310979700002OAI: oai:DiVA.org:liu-86392DiVA: diva2:576865
Note

Funding Agencies|project of Development and Research of Science Technology of Hebei Province, China|07276195011276103D-40|

Available from: 2012-12-14 Created: 2012-12-14 Last updated: 2017-12-06

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Sun, Xiao-Feng

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