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Analysis of the relationship between UV-absorbance of solute contents during a dialysis session
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Linköping University, Department of Medicine and Care, Nephrology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
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(English)Manuscript (preprint) (Other academic)
Abstract [en]

In this paper, the influence from patient anamnesis and haemodialysis session specifications onto the relationship between obtained ultra violet (UV) absorbance and urea concentration in the spent dialysate were discussed. A characterisation of the relationship was done by an intercept value and a slope. Recently, a new a dialysate monitoring device, using UV- absorbance, been developed by our group which has found a relationship between the UV- absorbance and waste products in the dialysate but this relationship vary between patients. In the present investigation, 13 patients performing totally 84 sessions were characterised using 31 possible affecting parameters. Using a multi-regression analysis 11 parameters were found significant as affecting parameters. In a novel mathematical model approach the obtained UV- absorbance and incorporating possible affecting parameters we could predict urea concentration from the UV-absorption in the spent dialysate in the total material of patients and dialysis sessions. For all the 84 sessions R2 between 0.938 and 0.996 were obtained. A performed analysis of variance rejects the assumption of equal conditions for the relationship between diabetics and non-diabetics patients in the material (F=5.2 for intercept and F=14.4 for slope). The urea concentration could be estimated with an accuracy of 11% (one standard deviation) which is normally clinically sufficient. The non-invasive UV -absorption method therefore seems to have great potential for monitoring and control haemodialysis sessions.

National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-86685OAI: oai:DiVA.org:liu-86685DiVA: diva2:580296
Available from: 2012-12-21 Created: 2012-12-21 Last updated: 2012-12-21
In thesis
1. Monitoring principles for haemodialysis
Open this publication in new window or tab >>Monitoring principles for haemodialysis
2002 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis deals with non-invasive monitoring techniques for haemodialysis. Three applications in particular have been investigated: Blood pressure measurements in the extra corporal circuit, the relationship between UV measurements and dialysate urea concentration and photoplethysmography (PPG) in haemodialysis patients.

A non-invasive pressure sensor as an integrated part of the extracorporeal tube circuit was developed using modified cross-section tube geometry. The expansions of the modified tubes with different cross-sectional geometries were studied upon application of pressure, both experimentally and numerically, using the finite element method. Factorial design was used to study the relationship between pressure in the tube and force needed to restore the expanding tube to its original dimension. This investigation was performed for different tube cross-sectional geometries. A pressure sensor was designed, based on the previously obtained findings. The evaluation of the pressure sensor showed that the output corresponded well to applied pressure (R2=0.99).

An UV-method for studying waste products in the dialysate has recently been developed by our research group. In the present study, it was investigated how the relationship between UV-absorption and dialysate urea concentration was affected by the treatment settings, patient anamnesis and prescribed pharmaceuticals. A mathematical model was proposed which includes these effects. Multiregression analysis indicated the possibility of performing individual estimates of urea concentration from UV-absorption.

During haemodialysis, the patient's cardiovascular system is affected when excess fluid is extracted, which may result in blood pressure fluctuations. In the present study, a novel PPG method for monitoring haemodynamic changes during dialysis was investigated. The performed study indicates that PPG measurements relate to haemodynamic changes and may thus be useful in the patient monitoring. However, the relationship is complex and needs further studies.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2002. 45 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 737
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24563 (URN)6728 (Local ID)91-7373-270-2 (ISBN)6728 (Archive number)6728 (OAI)
Public defence
2002-05-21, Aulan, Administrationshuset, Universitetssjukhuset, Linköping, 10:15 (Swedish)
Opponent
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2012-12-21

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Andersson, RogerFridolin, IvoMagnusson, MartinAsk, PerLindberg, Lars-Göran

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Andersson, RogerFridolin, IvoMagnusson, MartinAsk, PerLindberg, Lars-Göran
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