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Modelling tumour oxygenation, reoxygenation and implications on treatment outcome
Stockholm University and Karolinska Institutet, Sweden.ORCID iD: 0000-0002-7101-240X
Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.ORCID iD: 0000-0001-8171-2541
2013 (English)In: Computational and Mathematical Methods in Medicine, ISSN 1748-670X (print), 1748-6718 (online), Vol. 2013, 141087Article in journal (Refereed) Published
Abstract [en]

Oxygenation is an important component of the tumour microenvironment,having a significant impact on the progression and management of cancer. Theoreticaldetermination of tissue oxygenation through simulations of the oxygen transportprocess is a powerful tool to characterise the spatial distribution of oxygenon the microscopic scale and its dynamics and to study its impact on theresponse to radiation. Accurate modelling of tumour oxygenation must take intoaccount important aspects that are specific to tumours, making the quantitativecharacterisation of oxygenation rather difficult. This review aims to discussthe important aspects of modelling tumour oxygenation, reoxygenation andimplications for treatment.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2013. Vol. 2013, 141087
Keyword [en]
tumour oxygenation; treatment modelling; reoxygenation
National Category
Cancer and Oncology
URN: urn:nbn:se:liu:diva-86719DOI: 10.1155/2013/141087ISI: 000314153500001OAI: diva2:580777
Available from: 2012-12-27 Created: 2012-12-27 Last updated: 2016-07-01Bibliographically approved

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Toma-Dasu, IulianaDasu, Alexandru
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