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Optical measurement of creatinine in spent dialysate
Tallinn University of Technology, Estonia.
Tallinn University of Technology, Estonia.
Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
Tallinn University of Technology, Estonia.
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2013 (English)In: Clinical Nephrology, ISSN 0301-0430, Vol. 79, no 2, 107-117 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of the study was to develop an optical method for the estimation of creatinine (Cr) removal during dialysis using UV-absorbance. Material and methods: 29 hemodialysis patients on chronic 3-times-a-week hemodialysis were studied in 6 separate studies. Double-beam pectrophotometer was used for the determination of UV-absorbance in the collected spent dialysate samples. A single wavelength (SW) and a multi-wavelength (MW) model were developed using stepwise regression utilizing Cr values from the laboratory as the dependent parameter. The reduction ratio (RR) and total removed Cr (TRCr) were estimated. Results: For blood-Cr RRb (mean ± SD) was 60.9 ± 5.0% (calibration set) and 58.1 ± 6.0% (validation set), for SW UVabsorbance RR_SW was 61.5 ± 5.9% and 57.3 ± 6.0%, and for MW UV-absorbance RR_MW was 65.8 ± 5.8% and 61.7 ± 6.4% respectively. RR_SW and RRb were not statistically different. RR_MW was higher compared to RRb (p < 0.05). TRCr_lab was 13.8 ± 3.8 mmol, TRCr_SW 14.5 ± 2.5 mmol and TRCr_MW 13.8 ± 2.6 mmol, being not statistically different. Conclusion: In summary, creatinine removal during dialysis can be estimated as reduction ratio and total removed creatinine with the UV-absorbance technique.

Place, publisher, year, edition, pages
2013. Vol. 79, no 2, 107-117 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-86763DOI: 10.5414/CN107338ISI: 000320840000004PubMedID: 23110769OAI: diva2:582186
Available from: 2013-01-03 Created: 2013-01-03 Last updated: 2013-08-23

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Fridolin, IvoUhlin, Fredrik
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Internal MedicineFaculty of Health SciencesDepartment of Nephrology
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