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Towards a human rotavirus disease model
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
Gothenburg University, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
2012 (English)In: CURRENT OPINION IN VIROLOGY, ISSN 1879-6257, Vol. 2, no 4, 408-418 p.Article in journal (Refereed) Published
Abstract [en]

While the clinical importance of human rotavirus (RV) disease is well recognized and potent vaccines have been developed, our understanding of how human RV causes diarrhoea, vomiting and death remains unresolved. The fact that oral rehydration corrects electrolyte and water loss, indicates that enterocytes in the small intestine have a functional sodium-glucose co-transporter. Moreover, RV infection delays gastric emptying and loperamide appears to attenuate RV diarrhoea, thereby suggesting activation of the enteric nervous system. Serotonin (5-HT) receptor antagonists attenuate vomiting in young children with gastroenteritis while zinc and enkephalinase inhibitors attenuate RV-induced diarrhoea. In this review we discuss clinical symptoms, pathology, histology and treatment practices for human RV infections and compile the data into a simplified disease model.

Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 2, no 4, 408-418 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-86900DOI: 10.1016/j.coviro.2012.05.006ISI: 000312112900006OAI: oai:DiVA.org:liu-86900DiVA: diva2:583022
Note

Funding Agencies|Swedish Research Council|A0320301|

Available from: 2013-01-07 Created: 2013-01-07 Last updated: 2013-01-07

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Hagbom, MarieSharma, SumitSvensson, Lennart

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