Towards a human rotavirus disease model
2012 (English)In: CURRENT OPINION IN VIROLOGY, ISSN 1879-6257, Vol. 2, no 4, 408-418 p.Article in journal (Refereed) Published
While the clinical importance of human rotavirus (RV) disease is well recognized and potent vaccines have been developed, our understanding of how human RV causes diarrhoea, vomiting and death remains unresolved. The fact that oral rehydration corrects electrolyte and water loss, indicates that enterocytes in the small intestine have a functional sodium-glucose co-transporter. Moreover, RV infection delays gastric emptying and loperamide appears to attenuate RV diarrhoea, thereby suggesting activation of the enteric nervous system. Serotonin (5-HT) receptor antagonists attenuate vomiting in young children with gastroenteritis while zinc and enkephalinase inhibitors attenuate RV-induced diarrhoea. In this review we discuss clinical symptoms, pathology, histology and treatment practices for human RV infections and compile the data into a simplified disease model.
Place, publisher, year, edition, pages
Elsevier , 2012. Vol. 2, no 4, 408-418 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-86900DOI: 10.1016/j.coviro.2012.05.006ISI: 000312112900006OAI: oai:DiVA.org:liu-86900DiVA: diva2:583022
Funding Agencies|Swedish Research Council|A0320301|2013-01-072013-01-072013-01-07