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Adult stem cells and their trans-differentiation potential-perspectives and therapeutic applications
Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada .
Department of Physiology, University of Manitoba, Winnipeg, Canada; Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.
Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada .
Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada.
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2008 (English)In: Journal of Molecular Medicine, ISSN 0946-2716, E-ISSN 1432-1440, Vol. 86, no 12, 1301-1314 p.Article in journal (Refereed) Published
Abstract [en]

Stem cells are self-renewing multipotent progenitors with the broadest developmental potential in a given tissue at a given time. Normal stem cells in the adult organism are responsible for renewal and repair of aged or damaged tissue. Adult stem cells are present in virtually all tissues and during most stages of development. In this review, we introduce the reader to the basic information about the field. We describe selected stem cell isolation techniques and stem cell markers for various stem cell populations. These include makers for endothelial progenitor cells (CD146/MCAM/MUC18/S-endo-1, CD34, CD133/prominin, Tie-2, Flk1/KD/VEGFR2), hematopoietic stem cells (CD34, CD117/c-Kit, Sca1), mesenchymal stem cells (CD146/MCAM/MUC18/S-endo-1, STRO-1, Thy-1), neural stem cells (CD133/prominin, nestin, NCAM), mammary stem cells (CD24, CD29, Sca1), and intestinal stem cells (NCAM, CD34, Thy-1, CD117/c-Kit, Flt-3). Separate section provides a concise summary of recent clinical trials involving stem cells directed towards improvement of a damaged myocardium. In the last part of the review, we reflect on the field and on future developments.

Place, publisher, year, edition, pages
Springer, 2008. Vol. 86, no 12, 1301-1314 p.
Keyword [en]
Autoimmune disease, G-CSF, Graft vs. host reaction, Stem/progenitor cell, Trans-differentiation
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Cell Biology Biochemistry and Molecular Biology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-86917DOI: 10.1007/s00109-008-0383-6ISI: 000261180100002OAI: oai:DiVA.org:liu-86917DiVA: diva2:583201
Available from: 2013-01-07 Created: 2013-01-07 Last updated: 2017-12-06

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Los, Marek Jan

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Journal of Molecular Medicine
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Cell BiologyBiochemistry and Molecular BiologyCell and Molecular Biology

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