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Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo
Department of Immunology and Cell Biology, Department of Hematology/Oncology, University of Münster, D-48149 Münster, Germany, and Department of Radiation Oncology, University of Tübingen, D-72076, Tübingen, Germany..
Department of Immunology and Cell Biology, Department of Hematology/Oncology, University of Münster, D-48149 Münster, Germany, and Department of Radiation Oncology, University of Tübingen, D-72076, Tübingen, Germany..
Department of Immunology and Cell Biology, Department of Hematology/Oncology, University of Münster, D-48149 Münster, Germany, and Department of Radiation Oncology, University of Tübingen, D-72076, Tübingen, Germany..
Department of Immunology and Cell Biology, Department of Hematology/Oncology, University of Münster, D-48149 Münster, Germany, and Department of Radiation Oncology, University of Tübingen, D-72076, Tübingen, Germany..
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2001 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 98, no 5, 1542-1548 p.Article in journal (Refereed) Published
Abstract [en]

Diverse death stimuli including anticancer drugs trigger apoptosis by inducing the translocation of cytochrome c from the outer mitochondrial compartment into the cytosol. Once released, cytochrome c cooperates with apoptotic protease-activating factor-1 and deoxyadenosine triphosphate in caspase-9 activation and initiation of the apoptotic protease cascade. The results of this study show that on death induction by chemotherapeutic drugs, staurosporine and triggering of the death receptor CD95, cytochrome c not only translocates into the cytosol, but furthermore can be abundantly detected in the extracellular medium. The cytochrome c release from the cell Is a rapid and apoptosis-specific process that occurred within 1 hour after induction of apoptosis, but not during necrosis. Interestingly, elevated cytochrome c levels were observed in sera from patients with hematologic malignancies. In the course of cancer chemo-therapy, the serum levels of cytochrome c in the majority of the patients grew rapidly as a result of increased cell death. These data suggest that monitoring of cytochrome c In the serum of patients with tumors might serve as a useful clinical marker for the detection of the onset of apoptosis and cell turnover in vivo. (C) 2001 by The American Society of Hematology.

Place, publisher, year, edition, pages
American Society of Hematology , 2001. Vol. 98, no 5, 1542-1548 p.
Keyword [en]
activation, acute myeloid-leukemia, Bcl-2, caspases, Chemotherapy, combination, drug-induced apoptosis, lymphoma, membrane, Mitochondria
National Category
Hematology Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-87016DOI: 10.1182/blood.V98.5.1542ISI: 000170685000037PubMedID: 11520805OAI: oai:DiVA.org:liu-87016DiVA: diva2:584244
Available from: 2013-01-08 Created: 2013-01-08 Last updated: 2017-12-06

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Los, Marek Jan

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