liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Role of ICE-related and other proteases in Fas-mediated apoptosis
GERMAN CANC RES CTR,DIV MOLEC ONCOL,W-6900 HEIDELBERG,GERMANY.
GERMAN CANC RES CTR,DIV MOLEC ONCOL,W-6900 HEIDELBERG,GERMANY.
GERMAN CANC RES CTR,DIV MOLEC ONCOL,W-6900 HEIDELBERG,GERMANY.
GERMAN CANC RES CTR,DIV MOLEC ONCOL,W-6900 HEIDELBERG,GERMANY.
1996 (English)In: Cell Death and Differentiation, ISSN 1350-9047, E-ISSN 1476-5403, Vol. 3, no 2, 177-184 p.Article, review/survey (Refereed) Published
Abstract [en]

Interleukin-1 beta-converting enzyme (ICE)-like proteases comprise a novel family of unusual cysteine proteases which have been implicated in programmed cell death in both invertebrates and mammals. Current available evidence indicates a role of ICE proteases as central executioners of apoptosis triggered by the cell surface receptor Fas (APO-1). The presence of multiple mammalian ICE proteases with partially overlapping but distinct activities suggests a complex proteolytic cascade which is induced upon Fas ligation. The precise role of single members of the ICE family in Fas-mediated apoptosis, however, is still unclear. Here, we summarize the present knowledge about the relevance of ICE proteases, their potential targets, and interaction with unrelated proteases in cell death mediated by Fas and other apoptotic stimuli.

Place, publisher, year, edition, pages
1996. Vol. 3, no 2, 177-184 p.
Keyword [en]
antibody, apo-1, cell-surface antigen, cpp-32, cytotoxicity, death gene ced-3, factor receptor superfamily, fas, ice, interleukin-1-beta converting enzyme, member, molecular-cloning, parp, proteases, tumor-necrosis-factor
National Category
Cell Biology Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-87077ISI: A1996UT34700004OAI: oai:DiVA.org:liu-87077DiVA: diva2:584826
Available from: 2013-01-09 Created: 2013-01-09 Last updated: 2017-12-06

Open Access in DiVA

No full text

Authority records BETA

Los, Marek Jan

Search in DiVA

By author/editor
Los, Marek Jan
In the same journal
Cell Death and Differentiation
Cell BiologyBiochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 215 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf