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How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?
IBET, Portugal University of Nova Lisboa, Portugal .
IBET, Portugal University of Nova Lisboa, Portugal .
IBET, Portugal University of Nova Lisboa, Portugal .
Newcastle University, England .
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2012 (English)In: Biotechnology Journal, ISSN 1860-6768, E-ISSN 1860-7314, Vol. 7, no 12, 1522-1529 p.Article in journal (Refereed) Published
Abstract [en]

This report highlights the potential of measurement, monitoring, modeling and control ((MC)-C-3) methodologies in animal and human cell culture technology. In particular, state-of-the-art of (MC)-C-3 technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in (MC)-C-3 are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting (MC)-C-3 research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.

Place, publisher, year, edition, pages
Wiley-VCH Verlag Berlin , 2012. Vol. 7, no 12, 1522-1529 p.
Keyword [en]
Biopharmaceuticals, Gene therapy, Mammalian cells, Stem cells, Viral vectors
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-87252DOI: 10.1002/biot.201200226ISI: 000312032500013OAI: oai:DiVA.org:liu-87252DiVA: diva2:587189
Available from: 2013-01-14 Created: 2013-01-14 Last updated: 2017-12-06

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Mandenius, Carl-Fredrik

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