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Increased insulin secretion and decreased glucose concentrations, but not allostatic load, are associated with stress-related exhaustion in a clinical patient population
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-2530-4126
University of Gothenburg, Sweden .
Sahlgrens University Hospital, Sweden AstraZeneca RandD, Sweden .
Institute Stress Med, Sweden University of Gothenburg, Sweden .
2013 (English)In: Stress, ISSN 1025-3890, E-ISSN 1607-8888, Vol. 16, no 1, 24-33 p.Article in journal (Refereed) Published
Abstract [en]

Allostatic load (AL) has been shown to be a useful marker of physiological strain during chronic stress and burnout in non-clinical working populations. The usability of the AL index for a clinical population with severe stress-related exhaustion was tested in this study. Thirteen biomarkers assembled as an AL index were analysed using blood samples from 90 patients with stress-related exhaustion (43 men and 47 women, age 31-61 years) and 90 healthy controls (46 men and 44 women, age 25-56 years). The AL scores did not differ between patients and controls. For men, some indication of higher cardiovascular risk was seen in the patient group: male patients had higher body mass index and waist-hip ratio and a poorer blood lipid status than male controls. We found lower plasma glucose concentrations in both female and male patients than those in controls. The male patients also showed increased fasting serum insulin concentrations. Further analysis using homeostasis model assessment for insulin resistance and beta-cell function showed indications of insulin resistance in the patient group, particularly in the males, and an increased insulin secretion in both male and female patients. In conclusion, AL index does not seem to capture plausible physiological strain in patients diagnosed with stress-related exhaustion. The finding of lower plasma glucose concentrations, probably due to higher insulin secretion, in patients with severe stress-related exhaustion, needs to be further investigated, including mechanisms and the clinical relevance.

Place, publisher, year, edition, pages
Informa Healthcare , 2013. Vol. 16, no 1, 24-33 p.
Keyword [en]
Allostatic load, beta-cell function, burnout, glucose, insulin resistance, stress-related exhaustion
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-87239DOI: 10.3109/10253890.2012.688082ISI: 000312225400004OAI: diva2:587251

Funding Agencies|Swedish government||

Available from: 2013-01-14 Created: 2013-01-14 Last updated: 2014-08-26

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